Mohammed Inayatullah
Postdoctoral Fellow(Bioinformatics)
Wellcome-Wolfson Institute for Experimental Medicine,
Queen's University Belfast, UK
Research
I am a computational biologist with vast experience in high-throughput data analysis of single-cell (scRNA-seq, scATAC-seq, 10X visium spatial transcriptome) as well as bulk multi-OMICS profiles (RNA-seq [in-house,TCGA,GEO etc.], ChIP-Seq, ATAC-seq, GRO-seq, fastGRO) derived from human tissues as well as cell lines. My recent work on meta-analysis of single-cell transcriptome profiles of Triple negative breast cancer (TNBC) has discovered novel biomarkers associated with chemoresistance in TNBC. I have further applied machine learning technique and build a model that can predict response to chemotherapy upfront in TNBC.
I have filed patent (UK patent: 2117299.4) for these biomarkers and now in a process of clinical validation which is require for multi-gene test development for guiding chemotherapy treatment in TNBC.
My research contribution has been acclaimed by several international journals (Molecular and Cellular Biology 2021, Frontiers in oncology 2020, Scientific reports 2019, Oncotarget 2019) including very high impact journals Nature Cell Biology (accepted for publication), EMBO Molecular Medicine (Under revision).
Recently I have been awarded as early career researcher under InnovateUK ICURe and Lean Launch Programme program for market validation of my research innovation. Additionally, I have written several fellowship (Marie Skłodowska-Curie Individual Fellowships, EMBO Postdoctoral Fellowships, 1851 Royal Commission Research Fellowship) as well as research grants (CRUK Programme Foundation Award, MRC Case for Support, Breast Cancer Now).
Furthermore, I am also engaged in experimental workflow designing, data analysis, interpretation of key findings, preparing high quality publication figures, writing a manuscripts of joint research projects with eminent institution such as The Institute of Cancer Research, London; The University of Edinburgh, Salk Institute for Biological Studies, USA. Additionally, I am also providing necessary data analysis support to other labs here at Queens University including supervision to PhD students, Master students on their research projects.
Research Skills
Single-cell Genomics
Systems & Network biology
ChIp-seq and ATAC-seq
ChIp-seq and ATAC-seq
Systems & Network biology
ChIp-seq and ATAC-seq
Systems & Network biology
Systems & Network biology
Systems & Network biology
RNA-seq
Epigenomics regulation
Systems & Network biology
Epigenomics regulation
Epigenomics regulation
Epigenomics regulation
Machine learning
Epigenomics regulation
Epigenomics regulation
Research fellowships awards
Early Career Researcher (UKRI Innovate-UK)
Post-doctoral Research Fellowship (Bioinformatics)
Post-doctoral Research Fellowship (Bioinformatics)
UKRI Innovate-UK, Midlands Innovation to Commercialisation of University Research (ICURe) Programme
Post-doctoral Research Fellowship (Bioinformatics)
Post-doctoral Research Fellowship (Bioinformatics)
Post-doctoral Research Fellowship (Bioinformatics)
Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University, United Kingdom
Neuroscience Ireland Travel Award, 2022
Neuroscience Ireland Travel Award, 2022
Neuroscience Ireland Travel Award, 2022
Neuroscience Ireland (NSI) was established in 2005 as Ireland’s National Neuroscience Society, and is a registered charity in the Republic of Ireland.
Research Associate (Bioinformatics)
Neuroscience Ireland Travel Award, 2022
Neuroscience Ireland Travel Award, 2022
Gujarat Biotechnology Research Centre (GBRC), Department of Science & Technology, Government of Gujarat, INDIA
Patent/IP
A multi-gene test for predicting chemotherapy response in TNBC
Title: Method of Prognosis
Subject: TNBC Gene Signature
United Kingdom Patent Application No.: 2117299.4
Filing Date: 30 November 2021
Publication
Inayatullah Shaikh,Mr. Afzal Ansari , Ms. Garima Ayachit , Dr. Priayanka Sharma , Mr. Swapnil Kumar , Dr. Prabhakar Pandit , Ms. Vibhisha Vaghasia , Ms. Zuber Saiyed , Ms. Labdhi Shukla , Dr. Shivarudrappa Bhairappanavar. In-silico analysis of Dietary derived miRNAs shows functional homology with human riboswitches of tumor suppressor potential. Cells-MDPI. (manuscript accepted).
Preeti Sharma, Garima Ayachit, Inayat Shaikh, Priyanka Sharma, Shivarudrappa B Bhairappanavar, Naveen Yadav and Jayashankar Das. Advent of microRNAs from research to clinical utility. Cells-MDPI (manuscript accepted).
Seminar conferences
Oral presentation and secure second prize in "POSTDOC SYMPOSIUM 2021" , at Queens University Belfast, UK
Abstract accepted in Oral presentation in “32nd Euro Congress on Cancer Science & Therapy” 7th to 8thMarch, 2019, Barcelona, Spain.
Oral presentation in “international summit on oral submucous fibrosis”, Vadodara, 6-8 October, 2018.
Poster presentation “7th International conference on Rare and Undiagnosed diseases Addressing patient needs for Rare Disorders in India”, 13-15th April 2019, New Delhi.
Presented poster and secure second prize in the “National conference on New Horizons in Cancer Biology” organized by Gujarat Cancer Research Institute GCRI, 2018.
Designed research projects
Development of Early diagnostic marker for Oral Cancer management via high throughput genomics. (Approved by GBRC, DST, Govt. of Gujarat)
Development of plant miRNA based formulation as targeted immunomodulator for Oral and breast cancer. (Approved by GBRC, DST, Govt. of Gujarat) .
Development of early Diagnostic Kit for Alzheimer's Disease. (Approved by GBRC, DST, Govt. of Gujarat) .
Role of dietary derived miRNA in human disease regulation”. (Approved by GSBTM, DST, Govt. of Gujarat).
Development of rapid and accurate PCR based detection kit for multidrug resistant (MDR) bacteria” (Approved by GSBTM, DST, Govt. of Gujarat).
Education
MSc. Bioinformatics
M.Phil. Bioinformatics
M.Phil. Bioinformatics
Veer Narmad South Gujarat University, Surat
M.Phil. Bioinformatics
M.Phil. Bioinformatics
M.Phil. Bioinformatics
Saurashtra University, Rajkot
Ph.D. Biotechnology
M.Phil. Bioinformatics
Ph.D. Biotechnology
Hemchandracharya North Gujarat University, Patan
Receiving certificate in International conference
Oral presentation in International conference
Interaction with Principal Scientific Advisor, Government of India
Bangalore BIO 2016
Bangalore BIO 2016
Bangalore BIO 2016
DNA barcoding conference
Vibrant Gujarat Global Summit 2017 with Nobel laureates
Vibrant Gujarat Global Summit 2017 with Nobel laureates
International conference, ICRISAT, Hyderabad
International conference, ICRISAT, Hyderabad
International Symposium On Computational Biology And Dna Computing, DA-IICT